SLE and Serum Complement: Causative, Concomitant or Coincidental?
نویسندگان
چکیده
منابع مشابه
SLE and Serum Complement: Causative, Concomitant or Coincidental?
Background Systemic Lupus Erythematosus (SLE) is an incurable autoimmune disorder with complement activation playing a key role in the pathogenesis of immune-mediated tissue injury. While quantifying complement to monitor SLE disease activity has been the standard of care since the 1950s, decreased complement levels are not consistently associated with flares. Objective We seek to clarify the...
متن کاملA joint occurrence of atypical behavioral lateralization and schizophrenia: coincidental or causative?
45 Human hands are architecturally symmetrical, yet distinctly different in their functional abilities. This seemingly unique human tendency to use the right hand rather than the left for fine motor function is observed in ~90% of the human population. The remaining ~10% are atypical (i.e. left-handers). In addition to clearly visible hand dominance in humans, there are other behavioural latera...
متن کاملComplement and its breakdown products in SLE.
The complement system has important protective functions in both the innate and the adaptive immune systems but can also, when inappropriately activated, cause tissue damage. Complement deficiency predisposes to infection and also to development of autoimmune disease, especially SLE, and complement is at the same time involved in the pathogenesis of this disease. In this review, various aspects...
متن کاملCell-bound complement activation products in SLE
Diagnosis of SLE is based on clinical manifestations and laboratory findings. Timely diagnosis and treatment are important to control disease activity and prevent organ damage. However, diagnosis is challenging because of the heterogeneity in clinical signs and symptoms, and also because the disease presents with alternating periods of flare and quiescence. As SLE is an autoimmune disease chara...
متن کاملUrokinase in rheumatoid arthritis: causal or coincidental?
The past 10 years have witnessed an increased interest in the plasminogen activation system and its potential role(s) in rheumatoid arthritis (RA). Two types of plasminogen activators (PAs), urokinase (uPA) and tissue type PA (tPA), which are structurally, immunologically, and genetically distinct, have been identified in mammals. Both PAs are secreted as a single chain protein, which in the ca...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Open Rheumatology Journal
سال: 2017
ISSN: 1874-3129
DOI: 10.2174/1874312901711010113